Publications

 
 
Refereed journal articles/book chapters:
  1. Costanzo, M., Kuzmin, E., van Leeuwen, J., Mair, B., Moffat, J., Boone, C., Andrews, B. “Global Genetic Networks and the Genotype to Phenotype Relationship”. Cell. 2019 Mar 21; 177: 85-100 [Abstract]

  2. Lee, W., Kalashnikov, N., Mock, S., Halaoui, R., Kuzmin, E., Putnam A.J., Takayama, S., McCaffrey, L., Park, M., Zhao, R., Leask, R. L., Moraes, C. “Dispersible hydrogel force sensors reveal patterns of solid mechanical stress in multicellular spheroid cultures”. Nature Communications. 2019 Jan 11; 10(1):144 [Abstract]

  3. Kuzmin, E.*, VanderSluis, B.*, Wang, W., Tan, G., Deshpande, R., Chen, Y., Usaj, M, Balint, A., Mattiazzi Usaj, M., van Leeuwen, J., Koch, E.N., Pons, C., Dagilis, A.J., Pryszlak, M., Wang, J.Z.Y, Hanchard, J., Riggi, M., Xu, K., Heydari, H., San Luis, B.J., Shuteriqi, E., Zhu, H., Van Dyk, N., Sharifpoor, S., Costanzo, M., Loewith, R., Caudy, A., Bolnick, D., Brown, G.W., Andrews, B.J., Boone, C., Myers, C.L. "Systematic Analysis of Complex Genetic Interactions". Science. 2018 Apr 20; 360 (6386): eaao1729 [Abstract]

  4. Knight, J.F., Sung, V.Y.C., Kuzmin, E., Couzens, E.L., de Verteuil, D.A., Coelho, P., Johnson, R.M., Ratcliffe, C., Gruosso, T., Smith, H.W., Lee, W., Saleh, S.M., Zuo, D., Zhao, H., Guiot, M.C., Davis, R.R., Gregg, J.P., Moraes, C., Gingras, A.C., Park, M. "KIBRA (WWC1) is a metastasis suppressor gene affected by chromosome 5q loss in triple negative breast cancer." Cell Reports. 2018 March 20; 22 (12): 3191-3205 [Abstract]

  5. van Leeuwen, J., Pons, C., Mellor, J.C., Yamaguchi, T.N., Friesen, H., Koschwanez, J. , Mattiazzi Ušaj, M., Pechlaner, M., Takar, M., Ušaj, M., VanderSluis, B., Andrusiak, K., Bansal, P., Baryshnikova, A., Boone, C.E., Cao, J., Cote, A., Gebbia, M., Horecka, G., Horecka, I., Kuzmin, E., Legro, N., Liang, W., van Lieshout, N., McNee, M., San Luis, B.J., Shaeri, F., Shuteriqi, E., Sun, S., Yang, L., Youn, J.Y., Yuen, M., Costanzo, M., Gingras, A.C., Aloy, P., Oostenbrink, C., Murray, A., Graham, T.R., Myers, C.L.,  Andrews, B.J., Roth, F.P., Boone, C. “Exploring genetic suppression interactions on a global scale”. Science. 2016 Nov 4; 354 (6312): aag0839-1 [Abstract]

  6. Costanzo, M., VanderSluis, B., Koch, E.N., Baryshnikova, A., Pons, C., Tan, G., Wang, W., Usaj, M., Hanchard, J., Lee, S.D., Pelechano, V., Styles, E.B., Billmann, M., van Leeuwen, J., van Dyk, N., Lin, Z., Kuzmin, E., Nelson, J., Piotrowski, J.S., Srikumar, T., Bahr, S., Chen, Y., Deshpande, R., Kurat, C.F., Li, S.C., Li, Z., Mattiazzi Usaj, M., Okada, H., Pascoe, N., San Luis, B.J., Sharifpoor, S., Shuteriqi, E., Simpkins, S.W., Snider, J., Garadi Suresh, H., Tan, Y., Zhu, H., Malod-Dognin, M., Janjic, V., Przulj, N., Troyanskaya, O.G., Stagljar, I., Xia, T., Ohya, Y., Gingras, A.C., Raught, B., Boutros, M., Steinmetz, L.M., Moore, C.L., Rosebrock, A.P., Caudy, A.A., Myers, C.L., Andrews, B., Boone, B. “A global genetic interaction network maps a wiring diagram of cellular function”. Science. 2016 Sep 23; 353 (6306): aaf1420 [Abstract]

  7. Kuzmin, E., Costanzo, M., Boone, C. “Synthetic Genetic Arrays: Automation of Yeast Genetics.” Cold Spring Harbor Protocols, 2016 (4): 441-447. [Abstract]

  8. Kuzmin, E., Costanzo, M., Boone, C. “Synthetic Genetic Array Analysis.” Cold Spring Harbor Protocols, 2016 (4): 448-461. [Abstract]

  9. Mann, P.A., McLellan, C.A., Koseoglu, S., Si, Q., Kuzmin, E., Flattery, A., Harris, G., Sher, X., Murgolo, N., Wang, H., Devito, K., de Pedro, N., Genilloud, O., Nielsen Kahn, J., Jian, B., Costanzo, M., Boone, C., Garlisi, C.G., Lindquist, S., Roemer, T. “Chemical genomics-based antifungal drug discovery: targeting glycosylphosphatidylinositol (GPI) precursor biosynthesis”. ACS Infectious Disease, 2015 Jan 9; 1(1):59-72. [Abstract]

  10. Kuzmin, E., Sharifpoor, S., Baryshnikova, A., Costanzo, M., Myers, C.L., Andrews, B., Boone, C. “Synthetic Genetic Array Analysis for Global Mapping of Genetic Networks in Yeast.” Yeast Genetics: Methods and Protocols, Methods in Molecular Biology. Ed. Smith J., and Burke D.J. Springer Protocols, Humana Press, 2014: 143-168. [Abstract]

  11. Deshpande, R., Asiedu, M., Klebig, M., Sutor, S., Kuzmin, E., Nelson, J., Piotrowski, J., Shin, S.H., Yoshida, M., Costanzo, M., Boone, C., Wigle, D.A., Myers, C.L. “A comparative genomic approach for identifying synthetic lethal interactions in human cancer.” Cancer Research. 2013 Aug 29. [Abstract]

  12. Wagih, O., Usaj, M., Baryshnikova, A., Vandersluis, B., Kuzmin, E., Costanzo, M., Myers, C.L., Andrews, B.J., Boone, C.M., Parts, L. “SGAtools: one-stop analysis and visualization of array-based genetic interaction screens.” Nucleic Acids Research. 2013 May 15; 1-6. [Abstract]

  13. Magtanong, L., Ho, C.H., Barker, S.L., Jiao, W., Baryshnikova, A., Bahr, S., Smith, A.M., Heisler, L.E., Choy, J.S., Kuzmin, E., Andrusiak, K., Kobylianski, A., Li, Z., Costanzo, M., Basrai, M.A., Giaever, G., Nislow, C., Andrews, B., Boone, C. “Dosage suppression genetic interaction networks enhance functional wiring diagrams of the cell.” Nature Biotechnology. 2011 May 15;29(6):505-11. [Abstract]

  14. Shimizu, M., Tropak, M., Diaz, R.J., Suto, F., Surendra, H., Kuzmin, E., Li, J., Gross, G., Wilson, G.J., Callahan, J.W., Redington, A.N. “Transient limb ischemia remotely preconditions through a humoral mechanism acting directly on the myocardium: evidence suggesting cross-species protection.” Clinical Science. 2009 Aug 3;117(5):191-200. [Abstract]

Manuscripts in submission:
  1. Kuzmin, E.*, VanderSluis, B.*, Nguyen Ba, A.N., Wang, W., Koch, N.E., Usaj, M., Khmelinskii, A., Mattiazzi Usaj, M., van Leeuwen, J., Kraus, O., Tresenrider, A., Pryszlak, M., Hu, M.C., Varriano, B., Costanzo, M., Knop, M., Moses, A., Myers, C.L., Andrews, B.J., Boone, C. “Exploring whole-genome duplicate gene retention with complex genetic interaction analysis” (in review)
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Conference proceedings talks:

  1. Kuzmin, E., Monlong, J., Li, R, Morin, G., Bourgey, M., Barber, J., Wintersinger, J., Martinez, R. C., Kuasne, H., Fortier, A., Kleinman, C., Morris, Q., Huang, S., Ragoussis, I., Bourque, G., Park, M. "Evolution of large copy number variants in breast cancer through genetic network rewiring". Canadian Society for Molecular Biosciences 62nd Annual Conference: Model Systems in Cancer Research, University of Montreal, Montreal, 2019

  2. Kuzmin, E., VanderSluis, B., M., Costanzo, M., Andrews, B., Myers, C.L., Boone, C. “Systematic Analysis of Complex Genetic Interactions”.  Evolutionary Systems Biology 2018, Wellcome Genome Campus, Cambridge, 2018

  3. Kuzmin, E., VanderSluis, B., Chen, Y., Deshpande, R., Usaj, M., Costanzo, M., Myers, C.L., Andrews, B., Boone, C. “Using complex genetic interactions to study fates of duplicated genes and higher order buffering among singletons” Systems Biology: Networks Meeting, Cold Spring Harbor Laboratory, Cold Spring Harbor, 2015

  4. Kuzmin, E., VanderSluis, B., Chen, Y., Deshpande, R., Usaj, M., Costanzo, M., Myers, C.L., Andrews, B., Boone, C. “Complex genetic interaction profiles reveal evolutionary fates of duplicated genes.” 31st International Specialized Symposium on Yeast, University of Nova Gorica, Nova Gorica, 2014 

  5. Kuzmin, E., VanderSluis, B., Chen, Y., Deshpande, R., Usaj, M., Nguyen, A., Moses, A., Costanzo, M., Myers, C.L., Andrews, B., Boone, C. “Complex genetic interaction profiles reveal evolutionary fates of duplicated genes.” Yeast Genetics and Molecular Biology Meeting, Washington University, Seattle, 2014 

  6. Kuzmin, E., VanderSluis, B., Chen, Y., Deshpande, R., Nguyen, A., Moses, A., Costanzo, M., Myers, C.L., Andrews, B., Boone, C. “Mapping Trigenic Interactions of Whole Genome Duplicates in Yeast.” RECOMB/ISCB, University of Toronto, Toronto, 2013 

  7. Kuzmin, E., VanderSluis, B., Costanzo, M., Myers, C.L., Andrews, B., Boone, C. “Mapping Trigenic Interactions of Whole Genome Duplicates.” The 13th International Conference on Systems Biology, University of Toronto, Toronto, 2012 

  8. Kuzmin, E., VanderSluis, B., Costanzo, M., Myers, C.L., Andrews, B., Boone, C. “Mapping Trigenic Interactions of Whole Genome Duplicates.” Yeast Genetics and Molecular Biology Meeting, Princeton University, Princeton, 2012 

Conference proceedings posters:
  1. Kuzmin, E., Monlong, J., Schwartz, M., Jannat, S., Rui, Li., Ragoussis, J., Bourque, G., Park, M. “Identigying selection pressures that maintain regions of chromosomal segment loss in triple negative breast cancer”. 12th IRIC International Symposium: Machine Learning + Biological Systems, Montreal, 2018

  2. Kuzmin, E., VanderSluis, B., Costanzo, M., Andrews, B., Myers, C.L., Boone, C. “Systematic Analysis of Complex Genetic Interactions”. 12th IRIC International Symposium: Machine Learning + Biological Systems, Montreal, 2018

  3. Fiola, S.A.M., Ganni, E., Lo, R., Kuzmin, E., Diaz, R.J. “Growth impairment under conditions favoring mitochondrial oxidative metabolism in a yeast model of cancer-associated isocitrate dehydrogenase mutation”. Society for NeuroOncology 23rd Annual Meeting and Education Day, New Orleans, 2018

  4. Lee, W., Kuzmin, E., Mok, S., Halaoui, R., McCaffrey, L., Park, M., Zhao, R., Leask, R.L., Moraes, C. “Mechanical Stress Patterns in Spheroids Arise from Outside-in Compaction During Tissue Formation”. Biomedical Engineering Society 2018 Annual Meeting, Atlanta, 2018

  5. Kuzmin, E., Bertomeu, T., Marcotte, R., Hart, T., Sablina, A., Moffat, J., Tyers, M., Park, M. “Co-operating mutations residing in regions of chromosomal segment loss associated with breast cancer”. Cancer Genomics European Molecular Biology Laboratory Conference, Heidelberg, 2017

  6. Kuzmin, E., Bertomeu, T., Hart, T., Sablina, A., Moffat, J., Tyers, M., Park, M. “Genetic interaction landscape underlying cancer-associated chromosomal segment loss”. Symposia on Cancer Research 2016: Cancer Evolution: Mechanisms of Vulnerability and Resistance, MD Anderson Cancer Center, Houston, 2016

  7. Kuzmin, E., VanderSluis, B., Chen, Y., Usaj, M., Costanzo, M., Myers, C.L., Andrews, B., Boone, C. “Surveying Triple Mutant Genetic Interaction Space in Yeast.”  27th International Conference on Yeast Genetics and Molecular Biology, Levico Terme, 2015

  8. Kuzmin, E., VanderSluis, B., Deshpande, R., Chen, Y., Usaj, M., Nguyen, A., Moses, A., Costanzo, M., Myers, C.L., Andrews, B., Boone, C. “Charting Triple Mutant Genetic Interaction Space in Yeast.” CIFAR Genetic Networks Meeting, Dana-Farber Cancer Institute, Brookline, 2014

  9. Kuzmin, E., VanderSluis, B., Baryshnikova, A., Costanzo, M., Myers, C.L., Andrews, B., Boone, C. “Mapping Trigenic Interactions in Yeast.” CIFAR Genetic Networks Meeting, New York University, New York City, 2011

  10. Magtanong, L., Ho, C.H., Barker S.L., Bahr, S., Kuzmin, E., Andrusiak, K., Baryshnikova, A., Jiao, W., Li, Z., Smith, A.M., Heisler, L.E., Giaever, G., Nislow, C., Andrews, B., Boone, C. “The 2μ MoBY-ORF overexpression plasmid library and its application in dosage suppression studies of S. cerevisiae essential genes.” Yeast Genetics and Molecular Biology Meeting, University of British Columbia, Vancouver, 2010

  11. Kuzmin, E., Diaz, R.J., Wilson, G.J. “Chloride Channel 2 and Protein Kinase C epsilon Protein Module in Ischemic Preconditioning of Isolated Rabbit Cardiomyocytes.” 12th Annual Symposium on Advances in Laboratory Medicine and 6th Annual Laurence E. Becker Symposium, Department of Paediatric Laboratory Medicine, Hospital for Sick Children, University of Toronto, Toronto, 2009

  12. Kuzmin, E., Diaz, R.J., Wilson, G.J. “Chloride Channel 2 and Protein Kinase C epsilon Protein Module in Ischemic Preconditioning of Isolated Rabbit Cardiomyocytes.” International Society for Heart Research, Baltimore, 2009

  13. Surendra, H., Kuzmin, E., Diaz, R.J., Wilson, G.J. “Selective blockade of delta and kappa opioid receptors abolishes protection induced by treatment with preconditioned plasma dialysate in isolated rabbit cardiomyocytes.” 9th Annual Cardiovascular Scientific Day, Heart and Stroke Richard Lewar Centre of Excellence in Cardiovascular Research, Toronto, 2008

  14. Kuzmin, E., Diaz, R.J., Hinek, A., Hossain, and Wilson, G.J. “CLC-3 Chloride Channels associate with a multiprotein kinase signalling complex in cardiomyocytes.” 52nd Biophysical Society/16th IUPAB International Biophysics Congress, Los Angeles, 2008

  15. Diaz, R.J., Wong, D., Kuzmin, E., Hinek, A., Hossain, T., and Wilson, G.J. “CLC-2 CL-Channels Associates with a Cell Membrane PKCepsilon/Src Kinase Signalling Module in Cardiomyocytes.” XIX World Congress of International Society for Heart Research, Bologna, 2007

  16. Kuzmin, E., Diaz, R.J., Hossain, T., Hinek, A., Bilton, H., and Wilson, G.J. “Chloride Channel-3 Associates with Protein Kinase Multiprotein Complex Involved in Protective Myocardial Ischemic Preconditioning.” 8th Annual Cardiovascular Scientific Day, Heart and Stroke Richard Lewar Centre of Excellence in Cardiovascular Research, Hospital for Sick Children, Toronto, 2007

Invited talks:

  1. Kuzmin, E. “Systematic Analysis of Complex Genetic Interactions”. School for Molecular and Theoretical Biology, Pompeu Fabra University, Barcelona, 2019

  2. Kuzmin, E. “Systematic Analysis of Complex Genetic Interactions”. Sanger Institute, Cambridge, 2018

  3. Kuzmin, E. “Surveying Genetic Interaction Space: From Yeast to Human”. Centre hospitalier de l’Universite de Montreal, Montreal, 2017

Goodman Cancer Research Centre | McGill University | Montreal | Canada